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Updated: May 13, 2025

Isolation of Lipoprotein Particles from Chicken Egg Yolk for the Study of Bacterial Pathogen Fatty Acid Incorporation into Membrane Phospholipids
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Isolation of Lipoprotein Particles from Chicken Egg Yolk for the Study of Bacterial Pathogen Fatty Acid Incorporation into Membrane Phospholipids

Published on: May 15, 2019

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结构分析显示了通过抗精神病药物penfluridol抑制Staphylococcus aureus脂酶的抑制方式

Julia Kitadokoro1, Takatsugu Hirokawa2,3, Masayuki Kamo4

  • 1Faculty of Molecular Chemistry and Engineering, Graduate School of Science and Technology, Kyoto Institute of Technology, Hashigami-cho, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.

Scientific reports
|April 14, 2025
PubMed
概括

研究人员确定黄是葡萄球菌黄金色脂酶 (SAL) 的强有力的抑制剂,这是细菌增殖的关键因素. 这一发现得到了晶体结构分析的证实,为开发针对黄金葡萄球菌 (Staphylococcus aureus) 的抗感染剂提供了新的途径.

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Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
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