带血IgA/M显示在子宫内对SARS-CoV-2的反应,与流通的变种相关的波动
Olivier Pernet1, Toinette Frederick2, Amila Adili3
1Maternal, Child, and Adolescent Center for Infectious Diseases and Virology, Division of Pediatric Infectious Diseases, University of Southern California, Keck School of Medicine of USC, and Los Angeles General Medical Center, Los Angeles, CA, USA. pernet@usc.edu.
Nature communications
|April 14, 2025
概括
在子宫内检测到的SARS-CoV-2感染标志物,包括IgA和IgM抗体,在28.7%的新生儿中检测到. 胎儿抗体患病率随着新变异的出现而波动,这表明对暴露的婴儿进行更密切的监测.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 在子宫内感染SARS-CoV-2被认为是罕见的,使用多同型血清学进行有限的系统评估.
- 以前的研究通常仅依赖PCR或IgM检测,可能低估胎儿暴露.
- 没有研究将子宫感染标志物与特定SARS-CoV-2变种的出现相关联.
研究的目的:
- 系统地评估带血液样本中的胎儿IgA和/或IgM抗体,作为宫内SARS-CoV-2感染的标志物.
- 调查检测到的胎儿抗体与循环的SARS-CoV-2变体之间的关系.
- 为了确定子宫内SARS-CoV-2暴露的流行率和时间趋势.
主要方法:
- 从1038名新生儿的剩余带血样本 (CBS) 系统测试了SARS-CoV-2特定的胎儿IgA和/或IgM抗体.
- 数据收集发生在2021年10月21日至2023年2月15日,在洛杉矶的一家医院.
- 进行了统计分析,以评估流行率,时间变化和与变体的相关性.
主要成果:
- 在28.7%的带血样本中检测到SARS-CoV-2特定的胎儿IgA和/或IgM抗体.
- 胎儿抗体的患病率因月份而异 (P=0.0144).
- 胎儿抗体患病率显示出与SARS-CoV-2变体波动相关的波动,在BA.1 (36%) 和BA.4/5 (48.8%) 波动期间达到顶峰.
结论:
- 多同型血清学显示,宫内SARS-CoV-2暴露的患病率高于此前估计的.
- 胎儿免疫反应标志物似乎在与流通的SARS-CoV-2主要变种相关的波动.
- 识别出生时在子宫内暴露于SARS-CoV-2的新生儿可能有助于对不良结果进行更密切的临床监测.
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