与代谢功能障碍相关的脂肪性肝病预测因子和手握强度之间可能存在关联
Suyeon Lee1, Jong-Koo Kim2, Taesic Lee3,4
1Department of Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, South Korea.
Scientific reports
|April 14, 2025
概括
代谢功能障碍相关的脂肪性肝病 (MASLD) 和肌肉力量显示出复杂的联系. 肝硬化指数 (HSI) 与手握力 (HGS) 有正相关,但这种关系受到BMI和糖尿病等因素的影响.
科学领域:
- 肝病学和老年病学 肝病学和老年病学
- 代谢健康和肌肉骨功能
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 和皮症与慢性疾病有关.
- 研究已经探索了这些条件之间的联系,专注于肝脏健康和肌肉力量.
研究的目的:
- 为了研究估计的MASLD (eMASLD) 之间的关联,通过肝硬化指数 (HSI) 确定,肌肉强度,通过手握强度 (HGS) 测量.
- 分析HSI和HGS之间的关系中的线性和影响因素.
主要方法:
- 利用了韩国国家健康和营养检查调查 (2014-2019) 的数据.
- 使用HSI评估eMASLD,使用HGS评估肌肉力量.
- 采用多变量模型和分层分析来研究关联.
主要成果:
- 在HSI和HGS之间发现了正相关性.
- ALT/AST比率和糖尿病状况与HGS显著相关.
- 在特定的小组中观察到线性 (高BMI的老年非糖尿病男性,没有糖尿病的年轻女性),而其他小组则显示出受ALT/AST,BMI和糖尿病影响的非线性关联.
- 对BMI进行调整时,发现HSI与肌肉力量之间存在负面关联,特别是在女性中.
结论:
- HSI和HGS之间的相互作用是复杂的,并受到肝脏特征的影响.
- 肝脏健康指标显著调节肝脏脂肪和肌肉力量之间的关系.
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