在儿童急诊室使用Ketorolac:系统性审查和元分析
Antimo Tessitore1, Luisa Zupin2, Fulvio Celsi3
1Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. antimo.tessitore.at@gmail.com.
European journal of pediatrics
|April 14, 2025
概括
凯托洛拉克有效治疗儿科急诊室的疼痛,但不优于其他止痛药. 需要进一步的研究来确定最佳使用和对儿童急性疼痛管理的比较有效性.
科学领域:
- 儿科急救医学 儿科急救医学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 急性疼痛是儿童急诊室 (ED) 访问的常见原因.
- 非类固醇抗炎药物 (NSAID) 和阿片类药物是治疗疼痛的标准选择.
- 凯托洛拉克,一种NSAID,经常被使用,需要对其儿科疗效进行评估.
研究的目的:
- 系统地审查和元分析儿科ED患者治疗急性疼痛的凯托洛拉克的有效性.
- 为了比较Ketorolac的疗效和优势与其他疼痛管理选择.
- 确定当前关于儿童使用凯托洛拉克的研究中的差距.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了PubMed和Web of Science (1991年至2023年2月) 的英语儿科研究.
- 包括评估凯托洛拉克用于ED中常见的急性疼痛条件的RCT.
主要成果:
- 八个RCT研究了凯托洛拉克的疗效,表明儿科证据有限.
- 凯托洛拉克在偏头痛,创伤和结等疾病中表现出可变的有效性.
- 分析显示,与阿片类药物和其他NSAID相比,镇痛性能没有显著差异.
结论:
- 凯托洛拉克在儿科ED患者的急性疼痛中似乎有效,但与其他止痛药相比,效果并不优越.
- 目前的证据不足以自信地推特定的干预措施.
- 进一步的研究至关重要,以确定最佳的凯托洛拉克剂量,管理和比较有效性.
相关概念视频
Adrenergic Agonists: Therapeutic Uses
685
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
685
Local Anesthetics: Common Agents and Their Applications
376
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
376
Antiasthma Drugs: Leukotriene Modifiers
163
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
163
Tonsillitis II: Management
96
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
96
Endoscopic Studies II: Thoracocentesis
178
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
178
Drug Delivery: Enteral Route
340
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
340

