顺氏通灵囊通过Nrf2/TGF-β1信号通路改善前列腺纤维化
Zi-Qiang Wang1, Peng Mao2, Bao-An Wang2
1School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, 712046, China.
Chinese journal of integrative medicine
|April 14, 2025
概括
舒安石林囊 (SSTL) 通过减少细胞增殖和原沉积,有效治疗前列腺纤维化 (PF). 治疗机制包括调节Nrf2/TGF-β1信号通路并减轻氧化应激.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 前列腺纤维化 (PF) 是一种显著的病理变化.
- 了解传统中医药对PF的治疗机制至关重要.
研究的目的:
- 调查Shuangshi Tonglin囊 (SSTL) 在治疗前列腺纤维化 (PF) 的治疗效果和潜在机制.
主要方法:
- 建立了PF的体外 (WPMY-1细胞) 和体内 (斯普拉格-道利大鼠) 模型.
- 评估细胞增殖,迁移和原沉积.
- 分析了包括FGF-23,E2,PSA和氧化应激指标在内的关键标志物.
- 通过Western blot和qRT-PCR研究了Nrf2/HO-1和TGF-β1/Smad信号通路.
主要成果:
- 在体外和体内,SSTL显著抑制了前列腺 stromal 细胞的增殖,迁移和原沉积.
- SSTL治疗减少了前列腺指数,改善了腺体形态,降低了FGF-23,E2和PSA的水平.
- SSTL改善了氧化应激,并调节了Nrf2/HO-1和TGF-β1/Smad通路,由蛋白质和mRNA表达水平的改变证明了这一点.
结论:
- 黄石通灵囊在治疗前列腺纤维化方面表现出显著的疗效.
- 治疗效果归因于对Nrf2/TGF-β1信号通路的调节和减少氧化应激.
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