稀有和新兴的酵母菌种的分子鉴定和抗真菌敏感性概况,这些酵母菌种会引起桃菌
Ahmad Jabrodini1,2, Esmaeel Eghtedarnejad1, Amirmahdi Ghanbarzadeh1
1Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC research notes
|April 14, 2025
概括
稀有酵母正在越来越多地导致甲状腺菌菌病,这是一种具有挑战性的指甲感染. 这项研究确定了七种罕见的酵母菌种,并发现大多数表现出高水平的可纳耐药性,影响了指甲真菌感染的治疗选择.
科学领域:
- 医学真菌学 医学真菌学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 甲状炎 (指甲感染) 正在增加,由罕见真菌引起的病例越来越多.
- 识别这些罕见的真菌及其抗真菌耐药性对于有效治疗至关重要.
- 不寻常的酵母菌种可能与常见的酵母菌种相比表现出明显的抗真菌敏感性.
研究的目的:
- 为了识别导致桃菌病的罕见酵母物种.
- 确定这些已识别的罕见酵母的抗真菌易感性概况.
主要方法:
- 隔离和识别了19种罕见和新兴酵母菌株,这些酵母菌株来自桃菌病例.
- 确定了七种不同的酵母菌种,包括Candida orthopsilosis和Clavispora lusitaniae.
- 进行了抗真菌敏感性测试,重点是最小抑制度 (MIC) 值.
主要成果:
- 从七个物种中确定了十九种罕见的酵母分离物:Candida orthopsilosis (47.36%),Clavispora lusitaniae (10.52%),Wickerhamiella pararugosa (10.52%),Naganishia diffluens (10.52%),Wickerhamomyces anomalus (10.52%),Cyberlindnera fabianii (5.26%),以及Meyerozyma caribbica (5.26%).这些分离物种中分离的酵母分离物种是:Candida orthhopsilosis (47.36%),Clavispora lusitaniae (10.52%),Wickerhamiella pararugosa (10.52%),Naganishia diffluens (10.52%),Wickerhamomyces anomalus (10.52%),Cyberlindnera fabianii (5.26%),以及Meyerozyma caribbica (5.26%) 等.
- 大多数这些罕见的酵母分离物表现出高的最低抑制度 (MIC) 值为fluconazole.
- 这表明对常见抗真菌药物的潜在耐药性.
结论:
- 罕见的酵母物种是桃菌病的重要病原体.
- 在这些新兴的真菌病原体中,富可纳抗性是令人担忧的.
- 需要进一步研究罕见酵母菌引起的乳头菌的有效治疗方法.
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