治疗性灌程序用于治疗牙牙周炎 (TIPTAP):一个三盲并行组随机控制的I/II期试验
Satnam Singh Virdee1, Nasir Zeeshan Bashir2, Melissa M Grant1
1Institute of Clinical Sciences, School of Dentistry & Birmingham Dental Hospital, University of Birmingham, Birmingham, UK.
International endodontic journal
|April 15, 2025
概括
使用17%乙二胺三酸 (EDTA) 释放牙细胞外基质组件 (dECM) 的内牙治疗显示,结果与传统的甲 (NaOCl) 灌相当. 这种方法可以促进周根组织的愈合,而不会产生不良影响.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
背景情况:
- 溶解的内源性牙细胞外基质组件 (dECM) 对于纤维的再生至关重要.
- 通过刺激间酶体干细胞活动,dECM可能会增强患病的周根细胞组织的愈合.
- 调查新灌策略对于周围根治愈是必不可少的.
研究的目的:
- 为了比较17%的乙烯二胺三酸 (EDTA) 和5.25%的二 (NaOCl) 灌方案之间的牙周内治疗结果.
- 评估这些灌剂对疼痛评分,周根组织液 (PTF) 中的炎症调解剂和病变大小的影响.
- 为了确定EDTA增强的dECM释放是否相当于无症状顶牙牙周炎的常规NaOCl灌.
主要方法:
- 随机分配了40颗患有无症状上牙周炎的单根牙,接受17%的EDTA或5.25%的NaOCl灌.
- 评估了疼痛评分,PTF炎症分析物 (O-link Target-48细胞因子阵列) 和病变大小 (圆束计算机断层扫描).
- 临床和放射性结果在一年后被评估;参与者,操作人员和评估人员被蒙蔽.
主要成果:
- 在两组中,一年的有利结果都很高 (NaOCl: 89.5%,EDTA: 94.1%),没有统计学上显著的差异 (p > 0.05).
- 在这两组中,中位数的损伤体积减少是显著的,EDTA的减少略大 (95.84%) 与NaOCl (92.5%) 相比.
- 十五种炎症分析物减少了预阻塞;IL-6和IL-18在EDTA组预阻塞 (p <0.05) 中显著增加.
结论:
- 用17%的EDTA促进dECM溶解的治疗灌,在一年内产生了与传统NaOCl协议相当的治疗结果.
- 没有报告严重的不良反应,这表明EDTA是牙周灌的安全替代品.
- 这些发现支持了基于dECM的再生策略在内牙治疗中的潜力.
相关概念视频
Hand hygiene
3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.1K
Suctioning the Nasopharyngeal Airway
316
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
316
Tonsillitis II: Management
105
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
105
Suctioning the Oropharyngeal Airway
190
In preparing for oropharyngeal airway suctioning, a nurse must gather all necessary equipment, including a suction unit with tubing, a prepackaged suction kit, sterile gloves, water or saline for irrigation, a water-soluble lubricant, and additional personal protective equipment (such as a gown, mask, and goggles) to control infections.
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
190
Handwashing III: During the Procedure and Post-Procedure Steps
1.5K
To wash hands properly, follow these steps:
1.5K
Tracheostomy Suctioning II: Procedure
191
Tracheostomy suctioning is a vital nursing procedure that involves removing secretions from the tracheostomy tube to maintain airway patency and prevent respiratory complications. Nurses need to understand the proper technique for tracheostomy suctioning to ensure patient safety and comfort. In this guide, we will outline the step-by-step process for performing tracheostomy suctioning, including preparing the sterile field, donning personal protective equipment (PPE), lubricating and connecting...
191


