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在注射毒品的人群中重新治疗C型肝炎病毒
Aurielle M Thomas1,2, Alain H Litwin3,4,5, Judith I Tsui6
1Department of Pharmacy Practice and Clinical Research, University of Rhode Island, Kingston, Rhode Island, USA.
概括
在注射毒品 (PWID) 的人群中,重新治疗C型肝炎病毒 (HCV) 的成功率很高. 迅速重新治疗对于消除HCV和改善PWID的健康结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肝炎C病毒 (HCV) 仍然是美国死亡的重要原因.
- 直接作用抗病毒 (DAA) 疗法是有效的,但注射毒品 (PWID) 的人的再治疗结果未得到充分研究.
- 这项研究解决了关于PWID中DAA再处理的知识差距.
研究的目的:
- 评估直接作用抗病毒药物 (DAA) 在注射药物使用者 (PWID) 中重新治疗的结果.
- 确定与成功的再治疗结果相关的因素.
- 在PWID中评估HCV护理模型的有效性.
主要方法:
- 从HERO研究的纵向数据分析,一个务实的随机试验.
- 在阿片类药物治疗计划和社区诊所中纳入DAA未经治疗的PWID.
- 在初始索福斯布维尔/韦尔帕塔斯维尔 (SOF/VEL) 治疗后符合再治疗条件的参与者的鉴定 (2016年9月至2021年9月).
- 使用费舍尔精确测试和韦尔奇2样本t测试,对未达到持续病毒学反应 (SVR) 或SVR后再感染的参与者进行比较.
主要成果:
- 104名参与者有资格接受再治疗;41.3% (43) 开始接受再治疗.
- 在重新治疗后获得SVR结果的25名参与者中,96% (24) 实现了SVR.
- 没有达到SVR的参与者比SVR后 (784天) 重新感染的参与者更早 (471天) 开始重新治疗.
结论:
- 与初始DAA治疗相比,PWID治疗实现了更高的SVR率.
- 迅速获得重新治疗对于HCV消除至关重要.
- 支持PWID获得及时的再治疗对个人和公共健康都有好处.
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