流通的食物过敏原特定抗体,超出IgG4,在酸性食道炎中升高
Manal Bel Imam1, Sayuri Iwasaki1, Sophieke Lems1
1Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
概括
性食道炎 (EoE) 涉及对食物过敏原的复杂免疫反应,IgG和IgA抗体水平高于IgG4. 这些独特的抗体配置文件可以指导个人饮食管理和EoE的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 胃肠病学 胃肠病学
背景情况:
- 性食道炎 (EoE) 是一种由食物过敏原引发的慢性T2反应炎症状况.
- 与IgE介导的过敏不同,EoE在食道活检和循环中显示出高的IgG4水平.
- 在EoE中,确切的免疫病原发生和抗体概况仍然不完全理解.
研究的目的:
- 调查食物过敏原特异性抗体同型是否在EoE中升高.
- 确定这些抗体水平是否与EOE中的疾病活性有所不同.
- 探索不同抗体子类在EoE病原和管理中的潜在作用.
主要方法:
- 来自活性EoE,非活性EoE和非EoE对照的血样本使用ELISA分析了特定于食品的IgG和IgA子类.
- 对素,乳清,小麦和蛋过敏原的特定抗体被量化.
- 食品特异性B细胞通过流细胞计测量在一组患者.
主要成果:
- 在EoE患者中证实了IgG4水平的升高,对素,小麦和蛋过敏原.
- 针对αS1-素的特定IgG,IgG2,IgG4,IgA1和IgA2在EoE和对照组之间以及在活性和非活性EoE之间存在差异.
- 乳酪衍生过敏原表现出不同的反应,Bos d 4偏爱IgG4和Bos d 5在EoE中显示出高的IgG和IgA亚类.
结论:
- EoE血表现出不同的抗体配置,包括超出IgG4的IgG和IgA亚类,表明对食物过敏原的复杂免疫反应.
- 这些差异性抗体反应可能对EoE的饮食管理策略具有临床意义.
- 没有循环的过敏原特异性B细胞表明,抗体的产生局限于炎症的食道,可能指导未来的治疗点.
相关概念视频
01:10Antibody Structure
58.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
58.1K
02:06Allergic Reactions
27.2K
Overview
27.2K
00:42Cross-reactivity
30.9K
Overview
30.9K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
174
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
174
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K