泰达爆发刺激是否准备好作为双极性障碍的临床治疗方法?
Yufei Wu1, Danni Yan1, Jianli Yang1
1Department of Clinical Psychology, Tianjin Medical University General Hospital, Tianjin, China.
Bipolar disorders
|April 15, 2025
概括
在此元分析中,theta爆发刺激 (TBS) 对双相情感障碍 (BD) 没有显著的抗抑郁作用. 虽然耐受性很好,但TBS并没有改善BD患者的抑郁症得分或缓解率.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 在双极性障碍 (BD) 治疗中,theta爆发刺激 (TBS) 的疗效仍未得到研究.
- 现有的关于BD的TBS研究给出了不确定的结果.
研究的目的:
- 系统地审查和元分析TBS在治疗双相情感障碍中的疗效.
- 综合了BD的TBS随机对照试验 (RCT) 的研究结果.
主要方法:
- 在多个数据库 (PubMed,Embase,PsycINFO等) 中进行全面的文献搜索. 在2023年7月30日之前.
- 包括评估TBS治疗对BD患者的影响的RCT.
- 随机效应模型对科恩的d或odds比率对抑郁症得分 (madrs),响应/缓解率和退学率的元分析.
主要成果:
- 八个RCT被纳入了元分析.
- 对于MADRS得分变化,反应和缓解率的整体效应大小分别为-0.81,1.07和0.74.
- TBS表现出良好的耐受性,没有报告重大不良事件.
结论:
- 目前的证据表明,TBS在双相情感障碍患者中缺乏显著的抗抑郁药疗效.
- 对于患有BD的人来说,TBS是一种耐受性良好的干预措施.
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