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阻塞性睡眠呼吸暂停患者的临床特征患者有残留的嗜睡

Xujun Feng^1,2, Ye Zhang^1,2, Yuan Shi¹

¹Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.

ERJ open research

|April 15, 2025

概括

阻塞性睡眠呼吸暂停 (OSA) 的持续正气道压力 (CPAP) 可能不能完全解决一些患者的嗜睡. 女性患者的BMI,AHI较低,CPAP坚持较差,更有可能经历残留过度嗜睡 (RES).

科学领域:

睡眠医学睡眠医学
呼吸系统医学呼吸系统医学
临床研究临床研究

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种常见的疾病,在睡眠期间重复出现上呼吸道崩的特征.
持续正气道压力 (CPAP) 是OSA的主要治疗方法,但一些患者尽管坚持,但仍会出现残留过度嗜睡 (RES).
了解RES患者的特征对于优化治疗结果至关重要.

研究的目的:

进行元分析,以确定与CPAP治疗的OSA患者中RES相关的临床特征.
为了确定可能预测或导致CPAP治疗后持续性嗜睡的因素.

主要方法:

在PubMed,Embase,Cochrane图书馆和科学网上进行了系统的文献搜索.
七项符合预先定义的纳入标准的研究被选择用于元分析.
分析了接受CPAP治疗的有或没有RES的OSA患者的临床数据.

主要成果:

接受CPAP治疗的有RES的OSA患者表现出更高的爱普沃思睡眠度和抑郁症得分.
这些患者在治疗前还具有较低的体重指数 (BMI) 和呼吸暂停-呼吸暂停指数 (AHI).
较差的CPAP坚持和女性与RES有显著的关联.

结论:

女性性别,较低的BMI和AHI,治疗前更大的白天嗜睡和抑郁症状,以及减少CPAP坚持是有RES的OSA患者的关键特征.
这些已识别的因素可以帮助早期识别有RES风险的患者,指导进一步治疗干预的必要性.
针对这些因素可以改善OSA患者的RES管理策略.

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