累计平均甘油三糖糖体质指数与CKD发病风险之间的关联
Yu Wang1, Bin Chen1, Chongsen Zang1
1Department of Nephrology, the First Hospital of Jilin University, Changchun, Jilin, China.
Frontiers in endocrinology
|April 15, 2025
概括
累积平均甘油三糖糖体质指数 (TyG-BMI) 与成人慢性病 (CKD) 风险增加有关. 长期监测TyG-BMI有助于早期识别CKD风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一个日益严重的全球健康问题.
- 三糖糖-体质指数 (TyG-BMI) 与CKD有很强的相关性.
- 关于TyG-BMI变化与CKD发病率之间的关联的研究有限.
研究的目的:
- 调查累计平均TyG-BMI和CKD发病率之间的关联.
- 使用来自全国代表性前性队列研究的数据来探索这种关系.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据.
- 使用ln[TG×FBG/2]×BMI.计算了TyG-BMI (2011-2015年) 的累计平均值.
- 使用后勤回归和受限立方线来分析关联.
主要成果:
- 总共有6117名参与者被分析,其中470例是4年来发生的CKD病例.
- 累计平均TyG-BMI较高的四分位数与CKD发病风险增加有关.
- 限制性立方线分析表明,累计平均TyG-BMI和CKD风险之间存在线性关联.
结论:
- 累积平均TyG-BMI是中年和老年人中CKD的独立风险因素.
- 长期监测TyG-BMI可以帮助识别患有CKD高风险的个体.
- 这一发现支持针对CKD预防的积极健康管理策略.
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