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Updated: May 13, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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在帕金森病模型中,化α-synuclein驱动线粒体功能障碍和调节障碍

Jie Jiao1, Weijin Liu1,2, Ge Gao1

  • 1Department of Neurobiology, Beijing Key Laboratory of Neural Regeneration and Repair, Beijing Key Laboratory on Parkinson's Disease, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, School of Basic Medical Sciences, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.

Frontiers in aging neuroscience
|April 15, 2025
PubMed
概括

酸化α-synuclein (p-α-syn) 通过破坏线粒体信号传递来驱动帕金森病. 抑制这种酸化可以挽救线粒体的功能,揭示了PD的新治疗点.

关键词:
帕金森病是帕金森氏症的一种疾病.运输的运输.线粒体功能障碍 线粒体功能障碍酸化的方法是:光化.α-synuclein 是一种同核蛋白.

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Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons10:03

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