在内镜检查中,塞马格卢提德与胃内存的关联:回顾性分析
Garrick Han Gu1, Connor Pauplis2, Taylor Seacor1
1Internal Medicine, UMass Memorial Health, Worcester, United States.
Endoscopy international open
|April 15, 2025
概括
赛马格卢提德是一种GLP-1激动剂,在内镜检查过程中显著增加了胃内存保留的风险. 使用塞马格卢提德减肥的患者面临的风险高于使用它治疗糖尿病的患者.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 葡萄糖类-1 (GLP-1) 激动剂,如塞马格卢提德,越来越多地用于糖尿病和体重管理.
- 这些药物对胃空化的作用以及对内镜手术的潜在影响仍然是人们感兴趣的领域.
研究的目的:
- 在食管胃二透镜 (EGD) 过程中,调查半谷氨酸治疗与留住的胃内容物 (RGC) 的存在之间的关联.
- 为了比较RGC的风险,患者使用西马格卢提德减肥与血糖控制.
主要方法:
- 采用了追溯病例控制研究设计.
- 接受GLP-1治疗的患者与对照组进行了比较,并使用倾向性得分匹配 (年龄,性别,BMI,EGD指示) 来匹配.
- 统计分析包括麦克纳马和曼-惠特尼测试.
主要成果:
- 在接受GLP-1治疗的患者 (12.5%) 与对照组 (1.3%) 相比,观察到显著更高的RGC率 (P < 0.0001).
- 使用塞马格卢提德减肥的患者的RGC率高于对照组 (23%) (P < 0.0001).
- 使用塞马格卢提德治疗糖尿病的患者的RGC率与对照组相似 (2.6%与对照组相比,P = 0.5).
结论:
- 在内镜检查期间,塞马格卢提德的使用与RGC的风险增加有关.
- 与用于血糖控制的患者相比,在使用塞马格卢提德减肥的患者中,RGC的风险似乎更高.
- 这些发现表明,在内镜手术前管理GLP-1激动剂的使用可能会产生临床影响.
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