神经性疼痛管理的进步:科学创新和临床实践之间的桥梁
Subodh Raj Khadka1, Pavani Karani2, Neha Gogineni3
1Medicine, Croydon University Hospital, London, GBR.
Cureus
|April 15, 2025
概括
本综述强调了治疗神经病和慢性疼痛的进展. 神经调节,再生医学和精密方法方面的创新正在改变疼痛管理,以获得更好的患者结果.
科学领域:
- 神经学和疼痛管理
- 专注于神经疼痛,包括神经病痛,偏头痛和慢性疼痛综合征.
背景情况:
- 神经元疼痛状况对全球健康构成重大负担.
- 审查了到2024年的现有文献,以确定当前的治疗策略.
研究的目的:
- 探索神经疼痛治疗当代进展.
- 强调具有临床翻译潜力的分析研究.
- 提供基于有关疼痛机制和创新的治疗方法的现代文学基础.
主要方法:
- 使用PubMed和谷歌学者进行了全面的文献审查.
- 搜索术语包括神经病痛治疗,慢性疼痛治疗,疼痛管理方法,神经调节,脊髓刺激,深度大脑刺激,体磁刺激,体直流刺激,Nav1.7抑制剂,生物制剂,药物输送系统,再生医学,干细胞移植,富血小板血,组织工程,生物标志物,机器学习和精密医学.
- 分析着重于疼痛机制,制药创新,神经调节,个性化疼痛管理和再生医学的研究.
主要成果:
- 在神经炎症研究和发现分子/遗传疼痛因素方面取得了重大进展.
- 开发选择性Nav1.7抑制剂,生物制剂和复杂的药物输送系统.
- 侵入性 (DBS,SCS) 和非侵入性 (tDCS,TMS) 神经调节技术的确定的作用.
- 有前途的再生方法包括干细胞治疗,PRP和组织工程.
- 通过基因组数据,生物标志物和机器学习,提高疼痛管理的精度.
- 伦理考虑和对阿片类药物替代品的需求至关重要,特别是在服务不足的人群中.
结论:
- 翻译研究,创新疗法和个性化医学的融合正在彻底改变神经疼痛管理.
- 这些进展有可能显著改善患者的治疗结果和提高生活质量.
- 持续关注可访问性和文化敏感的护理是必不可少的.
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