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在一般人群和患有全身性巨细胞瘤的患者中,火毒过敏症的流行率
Jeremy C McMurray1,2, Brandon J Schornack1,2, Karla E Adams3
1Allergy & Immunology Service, Walter Reed National Military Medical Center, Bethesda, MD, United States.
Frontiers in allergy
|April 15, 2025
概括
在一般人群和全身性乳腺细胞瘤患者中,火毒的过敏反应比飞行的过敏反应更为普遍. 这种过敏反应往往被误诊,并且在全身性乳腺细胞瘤病例中未得到充分治疗.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 刺痛的黄虫毒液可能导致致命的过敏反应,特别是在有系统性巨细胞瘤的个体中.
- 侵入性火物种 (Solenopsis invicta和S. richteri) 迅速殖民了新的大陆.
- 在一般人群和全身性乳腺细胞瘤患者中,火毒过敏的患病率在很大程度上是未知的.
研究的目的:
- 为了确定火毒过敏症在Tricare受益人群中的患病率.
- 评估在被诊断为全身性巨细胞瘤的患者中,火毒过敏症的患病率.
- 为了研究系统性乳腺细胞瘤中火毒的过敏反应治疗模式.
主要方法:
- 查询的免疫疗法处方数据库 虫毒液和火全身提取物.
- 使用的Tricare受益人群健康登记册,用于Hymenoptera毒液过敏 (HVA) ICD-10代码.
- 对150名HVA患者进行了图表审查,并对全身性巨细胞瘤患者进行了回顾性分析.
主要成果:
- 火免疫疗法处方非常频繁,在几个州超过飞的处方.
- 一般人口患病率:火毒过敏症 (0.048%),飞虫毒过敏症 (0.083%).
- 在殖民国家,火毒过敏的患病率为0.085%;系统性巨细胞瘤患者经历了更多的火诱导的过敏,而不是飞诱导的过敏.
结论:
- 在一般人群和殖民地区的全身性乳腺细胞瘤患者中,火毒过敏比飞虫毒过敏更为常见.
- 在全身性乳腺细胞瘤中,火毒的过敏反应经常被误诊.
- 上腺素治疗在系统性乳腺细胞瘤患者的火毒过敏症中未得到充分利用.
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