喘共存如何影响CRSwNP管理中的生物疗法的战略选择?
Imran Ozdemir1, Nuray Bayar Muluk2, Mustafa Yazır3
1Department of Pulmonology, Medical Faculty, Üsküdar University, Istanbul, Türkiye.
Frontiers in allergy
|April 15, 2025
概括
诸如dupilumab,omalizumab和mepolizumab之类的生物疗法在喘并存时有效治疗具有鼻息肉的慢性鼻炎 (CRSwNP). 这些治疗向特定的炎症途径,改善两种疾病患者的治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 具有鼻息肉的慢性鼻炎 (CRSwNP) 经常与喘和AERD喘同时发生,具有共同的致病机制.
- 在CRSwNP和喘中的炎症途径可能是异质的,涉及2型或非2型炎症.
- 同时存在的喘会加剧下呼吸道炎症,并降低CRSwNP患者的喘控制.
研究的目的:
- 审查喘的共存和生物疗法的选择,用于CRSwNP管理.
- 探索向生物药物在治疗伴随性喘的CRSwNP中的作用.
主要方法:
- 通过使用PubMed,EBSCO,Proquest Central,Google和Google Scholar进行了全面的文献审查.
- 从2000年到2024年,搜索的术语包括"CRSwNP"",喘"",生物疗法"",Dupilumab"",Omalizumab"和"mepolizumab".
主要成果:
- 患有CRSwNP的患者往往同时存在下呼吸道疾病,特别是喘.
- 诸如dupilumab,omalizumab和mepolizumab之类的生物药物已被FDA批准用于CRSwNP治疗.
- 欧洲指导方针为CRSwNP的生物治疗提供了明确的指示,同时出现喘是关键标准.
结论:
- 生物治疗为患有同时存在CRSwNP和喘的患者提供了一个有前途的治疗选择.
- 在这种患者群体中,建议使用奥马利祖马布,杜皮卢马布和梅波利祖马布作为生物治疗方法.
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