由SARS-CoV-2引起的感官干扰:对临床表型,分子病理和可能的干预措施进行叙事性审查
Randal A Serafini1, Justin J Frere2, Ilinca M Giosan3
1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA.
Brain, behavior, & immunity - health
|April 15, 2025
概括
感染SARS-CoV-2可以导致长期的感官系统功能障碍,影响嗅觉,味觉,视觉和听觉. 需要更多的研究来了解这些持续的影响,并为COVID-19相关的感官障碍开发有效的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 眼科医生 眼科 眼科
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 随着COVID-19的流行,人们对SARS-CoV-2感染的急性和后急性影响产生了显著的临床兴趣.
- 对SARS-CoV-2对特殊感官系统的影响的全面了解仍然不完整.
- 正常的感官功能对生活质量至关重要,因此对感官系统障碍的研究至关重要.
研究的目的:
- 审查有关SARS-CoV-2引起的感觉神经系统损伤的尚未解决的问题.
- 突出SARS-CoV-2对嗅觉,味觉,体感,视觉和听觉系统的影响.
- 识别有关感官功能障碍病变和治疗的知识差距.
主要方法:
- 对现有文献进行了叙事审查.
- 研究包括人类生物样本,人类衍生的细胞系和动物模型.
- 文学专注于传染病学,病理机制和感官干扰的治疗策略.
主要成果:
- SARS-CoV-2 感染与所有感官系统的持续功能障碍有关.
- 有证据表明,嗅觉上皮质/球泡,体感性和味觉系统正在发生炎症.
- 观察到中枢和外周神经系统的长期转录变化以及味觉/视觉系统的退化.
结论:
- 虽然嗅觉,视觉和体感官系统得到了更多的关注,但对于COVID引起的损伤仍然需要治疗方法.
- 需要进一步的研究来开发基于证据的治疗方法来治疗这些感官异常.
- 需要更多地关注味觉,视觉和听觉系统,以阐明它们的致病性.
关键词:
听觉/前体功能 听觉/前体功能在 COVID-19 疫情中,品味 味道 味道 味道 味道长时间的COVID.嗅觉是一种嗅觉.这就是SARS-CoV-2病毒.身体上的感觉 (somatosensation) 是一种感觉.视觉 视觉 视觉 视觉 视觉 是一个更多相关视频
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