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Jian Huang¹, Deping Song², Jiazhen Wei³

¹Key Laboratory of Agro-product Quality and Safety of Jiangxi Province, Institute for Quality & Safety and Standards of Agricultura Sciences, Jiangxi Academy of Agricultural Sciences, Nanchang, Jiangxi, China.

Frontiers in microbiology

|April 15, 2025

概括

盖塔病毒 (GETV) 正在亚洲和大洋洲蔓延. 这项研究在74%的猪群中发现了GETV,确定了与增加毒性相关的关键突变.

科学领域:

兽医病毒学兽医病毒学
分子流行病学分子流行病学
亚博病毒学亚博病毒学

背景情况:

吉塔病毒 (GETV) 是蚊子传播的阿尔法病毒,对亚洲和大洋洲的动物健康构成越来越大的威胁.
GETV感染发生在马,猪和蓝狐身上,造成了巨大的经济损失.
扩大流行病地区迫切需要流行病学监测和遗传特征.

研究的目的:

调查野猪种群中GETV的流行病状况.
分析GETV菌株的遗传和进化模式.
为了识别GETV病毒性的分子决定因素.

主要方法:

在猪群中进行了GETV的调查 (n=77).
进行了基因组分析,包括代表性菌株 (JX2024) 的完整基因组测序.
利用了E2基因的遗传学分析和多重比较.

主要成果:

74.02%的测试样本为GETV阳性.
在腹小猪和堕胎胎儿的内脏组织中观察到最高的阳性率 (100%).
在牛奶和精液中首次检测到GETV.
代表性菌株JX2024属于GIII亚型.
在E2基因中,一个关键的氨基酸突变 (位于253位置的氨酸转化为氨酸) 与增强的GETV毒性有关.

结论:

GETV在野猪群中普遍存在,在特定组织中感染率高.
在牛奶和精液中检测到GETV突出显示了潜在的传播途径.
基因分析揭示了GETV亚型GIII,并确定了关键的毒性相关突变.
这项研究为了解中国GETV流行病学和演变提供了关键数据.

关键词:

盖塔病毒病毒.流行病学流行病学基因组测序是指基因组测序.遗传学分析遗传学分析野猪野猪是一种野生动物.

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