在精神病发作后的前三年,稳定的白质结构
Peter C Van Dyken1, Kun Yang2, Andreia V Faria3
1Neuroscience Graduate Program, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Biological psychiatry global open science
|April 15, 2025
概括
早期精神分裂症没有显示白质变性. 然而,现有的白质变化可能与精神分裂症患者的负面症状和疾病严重程度有关.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 扩散张力成像 扩散张力成像
背景情况:
- 白质变化是慢性精神分裂症的标志.
- 这些白质变化的时间在精神分裂症仍然不清楚.
- 之前的横截面研究无法区分退行过程和先前存在的脆弱性.
研究的目的:
- 为了研究早期精神分裂症中白质变化的纵向轨迹.
- 为了将白质变化与精神分裂症患者的临床症状相关联.
主要方法:
- 对28名精神分裂症患者和42名对照患者2年内160次扩散张力成像 (DTI) 扫描的纵向分析.
- 使用7T扫描仪验证,采用19名第一发作精神分裂症患者和15名对照者的6个月随访数据.
- DTI参数与阳性和阴性症状得分的基于兴趣的相关性区域.
主要成果:
- 在精神分裂症患者和对照参与者之间没有发现DTI参数的显著纵向差异.
- 在两个数据集中,白质变化和负面症状之间观察到一致的关联.
- 在早期精神分裂症中没有发现积累白质退化的证据.
结论:
- 白质似乎不会在精神分裂症的早期阶段发生退化.
- 以前存在的白质病理可能与精神分裂症疾病的严重程度有关.
- 研究结果表明,精神分裂症中的白质变化可能反映了先前存在的脆弱性,而不是疾病驱动的退化.
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