高水下内镜粘膜切除的高完全切除率对于中等大小的状状病变
Junki Toyosawa1, Masayasu Ohmori2, Yasushi Yamasaki1
1Department of Gastroenterology, Okayama University Hospital, Okayama, Japan.
概括
水下内镜粘膜切除 (UEMR) 为中等大小的状状病变 (SSL) 提供了可接受的完整切除率. 这种技术可能成为SSL的标准治疗方法,改善患者的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 在瘤学瘤学.
背景情况:
- 状状病变 (SSL) 是癌前的,需要进行完整的内镜切除.
- 传统的内镜粘膜切除 (EMR) 对中等尺寸的SSL有局限性.
- 水下EMR (UEMR) 对SSL的疗效尚未得到充分证实.
研究的目的:
- 为了评估中等尺寸SSL的UEMR的完整切除率.
- 评估UEMR在管理SSL中的安全性和有效性.
主要方法:
- 在两个机构进行的前性,单臂的观察性研究.
- 103名中等尺寸SSL (10-20毫米) 的患者接受了UEMR.
- 进行了组织学评估,切除后检查和1年的随访结肠镜检查.
主要成果:
- 完全切除率为97% (95% CI: 91.8-99.0%).
- R0切除和块切除率分别为61%和91%.
- 在87个随访病变中没有观察到复发;只有一个不良事件 (延迟出血) 发生.
结论:
- 对于中等尺寸的SSL,UEMR显示了可接受的完整切除率.
- UEMR显示承诺作为SSL的标准治疗选择.
- 该程序与不良事件的低率有关.
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