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在周围肺癌病变中对Sonazoid和SonoVue对比增强超声波定量分析参数进行比较研究
Guosheng Liang1, Wuxi Chen1, Jiaxin Tang2
1Department of Ultrasound, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Journal of clinical ultrasound : JCU
|April 15, 2025
概括
这项研究比较了Sonazoid和SonoVue对比剂用于使用对比增强超声波 (CEUS) 诊断肺癌. 虽然这两种药物的性能相似,但Sonazoid显示出较高的损伤-肺部对比度,可能改善周边肺癌病变的诊断准确性.
科学领域:
- 医疗成像医学成像
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 肺癌仍然是死亡的重要原因,需要在诊断技术的进步.
- 对比增强超声波 (CEUS) 是一种不断发展的成像方式,用于评估各种病理,包括肺病变.
- 对CEUS的定量分析可以为病变的表征和诊断提供客观数据.
研究的目的:
- 为了比较Sonazoid和SonoVue对比剂在使用CEUS对外肺癌病变 (PLCLs) 的定量分析中的性能.
- 评估关键的定量CEUS指标,以区分PLCL与相邻的肺组织.
主要方法:
- 一项回顾性研究涉及103名患有PLCL的患者,分为Sonazoid-CEUS和SonoVue-CEUS组.
- 在病变和相邻的正常肺组织中定义了感兴趣的区域,以生成时间强度曲线.
- 分析了七个CEUS定量指标,包括到达时间 (AT),峰值强度 (PI),曲线下的面积 (AUC),到达峰值的时间 (TTP),平均过渡时间 (MTT) 和损伤-肺PI差异 (ΔPI).
主要成果:
- 对于PLCL和相邻的肺组织,Sonazoid和SonoVue之间的到达时间 (AT) 没有显著差异.
- 与SonoVue组相比,Sonazoid组的病变峰值强度 (PI) 和曲线下面积 (AUC) 显着较低 (p < 0.001).
- 相反,Sonazoid组表现出显著更高的高峰时间 (TTP),平均过渡时间 (MTT) 和损伤-肺PI差异 (ΔPI) (TTP和MTT的p <0.001,ΔPI的p <0.01).
结论:
- 在PLCL的CEUS中,Sonazoid和SonoVue显示了可比的定量性能.
- 索纳德的显著更高的 ΔPI 表明病变和周围的肺组织之间的对比性增强,可能有助于诊断.
- 这些发现可能有助于改善对周边肺癌的诊断策略.
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