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基于休息状态fMRI的脊柱斜不平衡患者的大脑活动

Chenglong Xie^1,2, Sunlong Li^1,2, Yifeng Shi^1,2

¹Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.

|April 15, 2025

概括

脊柱松不平衡 (SSI) 患者在关键运动和感官区域的大脑活动发生变化. 这些大脑变化,特别是区域同质性 (ReHo),可以作为SSI患者诊断和治疗的生物标志物.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
整形外科整形外科整形外科

背景情况:

脊柱斜腰不平衡 (SSI) 与步态和平衡问题有关.
大脑在姿势-步态控制中的作用是复杂的,但在SSI中并不完全理解.
对SSI患者大脑功能差异的研究是有限的.

研究的目的:

为了研究脊柱松不平衡 (SSI) 患者的大脑区域同质性 (ReHo) 的变化.
探索大脑ReHo与SSI患者的临床测量之间的关系.

主要方法:

一项涉及20名SSI患者和20名健康对照者的横截面研究.
休息状态功能磁共振成像 (rs-fMRI) 用于评估大脑活动.
统计分析发现了ReHo的差异和与临床评分的相关性.

主要成果:

与对照人群相比,SSI患者在左小脑Crus 1,右上神经,中间右上额头和左补充运动区域的ReHo增加.
这些地区的ReHo值与奥斯韦斯特里残疾指数 (ODI),身体功能和斜腰垂直轴 (SVA) 等临床指标相关.

结论:

在SSI患者的特定大脑区域存在显著的ReHo变化.
异常的ReHo可以作为一种潜在的生物标志物,用于理解,诊断和治疗脊柱斜不平衡.

关键词:

功能性磁共振成像技术功能性磁共振成像技术圣角不平衡是指圣角的不平衡.脊柱形症是一种脊柱形症.

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