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使用配对的miRNA来分层对良性乳腺病变的异常乳房图的逻辑回归模型的性能

Hideo Akiyama1, Lora Barke2, Therese B Bevers3

  • 1Toray Industries, Inc., Kamakura, Kanagawa, Japan.

Cancer medicine
|April 15, 2025
PubMed
概括

一个新的microRNA (miRNA) 分类器EarlyGuard在识别异常乳腺造影后不太可能患乳腺癌的女性方面表现出高准确性. 这种分子测试可以减少不必要的活检和对低风险个体的随访成像.

关键词:
异常的乳房扫描是异常的良性乳腺病变 良性乳腺病变乳腺癌 乳腺癌 乳腺癌液体活检活检液体活检血清中的miRNA

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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