在喘患者中,因COVID-19 Omicron变异引起的咳治疗恩西特瑞尔维尔的有效性
Naoyuki Miyashita1, Nobuyuki Horita2, Yasushi Nakamori3
1First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, Hirakata, Japan.
Microbiology spectrum
|April 15, 2025
概括
恩西特利维尔在COVID-19 Omicron变种感染后,有效治疗了喘患者的持续咳. 与症状治疗相比,早期使用恩西特莱尔维尔显著改善了咳症状和生活质量.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有喘的患者面临着急性COVID-19后咳的更高风险,特别是在Omicron变种激增期间.
- 持续咳是COVID-19感染后喘患者的一个重大问题.
研究的目的:
- 评估恩西特雷尔维尔在治疗喘患者COVID-19 Omicron变种相关的咳中的疗效.
- 评估恩西特雷尔维尔对咳严重程度,频率和生活质量的影响.
主要方法:
- 一项涉及223名喘患者的研究,他们患有COVID-19 Omicron变种相关的咳.
- 患者被分为两个组:恩西特雷尔维尔治疗 (121) 和症状治疗 (102).
- 咳症状和生活质量使用日本版莱斯特咳问卷 (J-LCQ) 在基线和4日,7日和14日测量.
主要成果:
- 与症状治疗组 (P <0.001) 相比,恩西特雷尔维尔治疗组在J-LCQ得分上显示出显著更大的改善 (P <0.001).
- 恩西特里尔维尔治疗与第四,第7和第14天的J-LCQ得分较高有关 (3.1分,3.5分和2.0分分别较高;P <0.001).
- 在基线接受三重吸入治疗的患者也在J-LCQ得分上显著改善 (P <0.001).
结论:
- 在喘患者中,早期服用恩西特里尔维尔在治疗COVID-19 Omicron变种引起的咳方面表现出有效性.
- 恩西特雷尔维尔在这个脆弱人群中提供了一种有前途的治疗选择,用于管理COVID-19后持续性咳.
- 这项研究强调了针对COVID-19后呼吸系统症状的向治疗在患有喘的患者中的重要性.
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