通过充电的甲纳米乳液使病毒无活化
Pragathi Kamarasu1, Minji Kim1, David Julian McClements1
1Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Foods (Basel, Switzerland)
|April 15, 2025
概括
肉甲纳米乳液显示对像人类冠状病毒229E这样的包裹病毒具有增强的抗病毒活性,但与单独使用肉甲油相比,对非包裹的MS2菌体效果较差.
科学领域:
- 环境科学 环境科学
- 病毒学 病毒学
- 纳米技术 纳米技术
背景情况:
- 病毒病原体对公众健康构成重大风险,需要有效的环境灭活方法.
- 丁甲,一种精油成分,具有已知的抗菌性质.
- 纳米乳液配方可以改变活性化合物的输送和疗效.
研究的目的:
- 为了比较金甲纳米乳液 (CNE) 和金甲油 (CNO) 的抗病毒功效.
- 评估对非包裹病毒代用物 (MS2菌体) 和包裹病毒 (人类冠状病毒229E) 的活性.
主要方法:
- 治疗MS2菌体和人体冠状病毒229E,使用不同度 (0.5-3.5%) 的CNE和CNO.
- 在治疗后化1小时.
- 使用斑块形成单位 (PFU/mL) 量化病毒减少.
主要成果:
- 在所有测试度中,CNO表现出明显更大的MS2减少,而不是CNE.
- 与高度 (≥2.5%) 的CNO相比,CNE对人类冠状病毒229E的疗效优于CNO.
- 对HuCoV-229E的日志减少为5.98 ± 0.12 (CNE) 与4.43 ± 0.38 (CNO) 在2.5%的甲.
结论:
- 纳米乳化增强了 cinnamaldehyde的抗病毒活性,对抗像人类冠状病毒229E.这样的包裹病毒.
- 针对包裹病毒的CNE增强的疗效可能是由于纳米滴的透率提高.
- 选择配方 (油与纳米乳液) 对于基于病毒类型的针对性抗病毒消毒至关重要.
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