在COVID-19大流行期间的术后间隔内静脉血栓栓塞的风险:元分析
Andrew Jackson1,2, Christopher A Lewis-Lloyd1,2, Oluwademilade Merotohun1,2
1Nottingham Digestive Diseases Centre, Division of Translation Medical Sciences, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
BJS open
|April 15, 2025
概括
在术后患者中,COVID-19显著增加了静脉血栓栓塞 (VTE) 风险,特别是那些经历了骨科和胃肠道手术而患有术前感染的患者. 疫情前和疫情前的VTE率没有显著差异.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 外科手术的结果
背景情况:
- COVID-19大流行与手术患者的静脉血栓栓塞 (VTE) 率上升有关.
- 在大流行期间,关于手术后静脉瘤发病率的数据有限.
- 术后COVID-19感染是增加VTE的潜在原因之一.
研究的目的:
- 在COVID-19大流行期间调查手术后VTE的全球发病率.
- 为了比较患有和没有外科手术期间COVID-19感染的患者之间的VTE病率.
- 分析大流行前和大流行期间的VTE发病率.
主要方法:
- 在多个数据库 (MEDLINE,Embase等) 的系统文献搜索. 从2019年1月开始到2023年11月.
- 包括在COVID-19大流行期间接受手术的成年患者的研究.
- 综合风险和发病率 (每1000人/年) 的分析,用于30或90天的术后静脉瘤.
主要成果:
- 分析包括了17项涉及300多万患者的研究.
- 在COVID-19阳性患者和COVID-19阴性患者中观察到显著更高的VTE率,涉及全关节关节整形术,其他骨科手术和紧急一般/胃肠道手术.
- 在比较大流行前和大流行期间时,没有发现VTE率的显著差异.
结论:
- 在COVID-19阳性患者的外科手术期间,VTE率持续上升,特别是在骨科和紧急胃肠道手术后.
- 需要进一步的研究来了解根据COVID-19变种和疫苗接种状态的VTE风险变化.
- 这些发现强调了需要在流行病期间为手术患者的VTE预防提供未来临床实践的信息.
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