相关实验视频

Updated: May 17, 2025

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

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简化tRNA合成酶进化为遗传码扩展和深度测序分析其进化变体的分析

Michael Shaferman, Itay Moshel, Shiran Dror

    ACS synthetic biology
    |April 15, 2025
    PubMed
    概括

    这项研究简化了定向进化,以增强pyrrolysyl-tRNA合成酶 (PylRS) 活动,以扩展遗传密码. 这种可访问的方法改善了非正规氨基酸的结合,这对于蛋白质工程至关重要.

    关键词:
    这是PylRS.遗传密码扩张 扩张负选择选择是负选择.阳性选择是一种积极的选择.在tRNA合成酶指导进化的过程中.双重突变 双重突变 双重突变

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