人类牛奶,婴儿配方奶粉及其橄糖的抗氧化和减轻炎症的能力

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Andrea Leong¹, Christopher Pillidge¹, Harsharn Gill¹

¹School of Science, RMIT University, Melbourne, VIC 3083, Australia.

Foods (Basel, Switzerland)

|April 15, 2025

概括

基于山羊奶的婴儿配方奶粉 (GIF) 和其寡糖化物 (GMO) 与基于牛奶的选择相比,显示出更高的抗氧化活性. 转基因生物还在细胞模型中显示出降低炎症标志物的潜力.

科学领域:

营养生物化学营养生物化学
免疫学免疫学免疫学
儿童营养学儿童营养学

背景情况:

人母乳 (HM) 是婴儿健康的最佳选择,因为它含有蛋白质和寡糖类 (HMO) 等生物活性成分.
婴儿配方奶粉 (IFs),包括牛奶 (CIF) 和山羊奶 (GIF) 类型的婴儿配方奶粉,是当HM无法使用时的替代品.
了解IF及其寡糖的特性对于婴儿营养至关重要.

研究的目的:

使用体外模型比较HM,CIF和GIF的抗氧化特性.
在U937细胞模型中评估HM寡糖化物 (HMOs),牛奶寡糖化物 (CMOs) 和山羊奶寡糖化物 (GMOs) 的抗炎作用.
评估这些牛奶来源及其寡糖的降铁和铁化能力.

主要方法:

实验室中抗氧化剂测试被用于评估降铁和铁化性质.
使用U937细胞培养模型来评估寡糖类对炎症标志物 (IL-1α,TNFα,IL-6,IL-8) 在炎症诱导后的影响.
对HM,CIF,GIF,HMOs,CMO和GMO进行了比较分析.

主要成果:

基于山羊奶的婴儿配方奶粉 (GIF) 和其寡糖化物 (GMO) 显示出最高的抗氧化能力.
CIF和GIF的降铁和铁化能力与HM相当;CMO显示铁化能力最低.
虽然没有任何一种寡糖化合物显著降低了U937细胞因子表达,但转基因生物始终比其他生物更能降低IL-1α,TNFα和IL-6水平,这表明潜在的免疫受体相互作用.

结论:

羊奶寡糖 (GMO) 具有比牛奶寡糖 (CMO) 更大的抗氧化潜力.
转基因生物可能具有减轻炎症的特性,可能是通过与免疫受体的竞争性结合.
对婴儿营养中山羊奶成分的生物活性进行进一步研究是有必要的.

关键词:

抗氧化剂是一种抗氧化剂.生物化学指数生物化学指数细胞培养模型的细胞培养模型细胞因子细胞因子基因表达婴儿配方奶粉的使用方法这是一种炎症炎症炎症炎症.牛奶中的寡糖是牛奶中的寡糖.

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