脂质纳米颗粒:配方,生产方法和表征协议
Fernanda L Lüdtke1,2, Thaís Jordânia Silva3, Mayanny Gomes da Silva4
1CEB-Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
Foods (Basel, Switzerland)
|April 15, 2025
概括
脂质纳米粒子 (LNs) 有效地提供脂质可溶化合物. 本综述详细介绍了脂质矩阵,乳化剂和生产方法,以获得稳定,高效的LNs,特别是用于食品应用.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 食品科学 食品科学 食品科学
背景情况:
- 脂质纳米颗粒 (LNs) 是脂质可溶生物活性化合物的先进输送系统.
- 固体脂质纳米粒子 (SLNs) 和纳米结构脂质载体 (NLCs) 显示出生物活性化合物封装的前景.
- 对脂质矩阵和乳化剂的最佳选择对LN疗效至关重要.
研究的目的:
- 审查过去15年来在LN生产中使用的脂质的化学,物理和结构特征.
- 分析LN生产方法和表征技术.
- 为食品系统确定生产稳定LNs的关键因素,具有高封装和传递效率.
主要方法:
- 对过去15年发表的研究进行了全面的文献综述.
- 在LN配方中分析脂质矩阵,乳化剂和生物活性化合物.
- 讨论关键的特征化技术,包括粒子大小,泽塔潜力,结晶性,热行为,形态,捕获效率,负载能力和物理稳定性.
主要成果:
- 详细检查与LN配方相关的脂质特性.
- 深入分析各种LN生产技术.
- 讨论影响LN稳定性和性能的关键参数.
结论:
- 精心选择脂质矩阵和乳化剂对于成功的LN发育至关重要.
- 了解生产方法和表征是优化LN性能的关键.
- 具有高效生物活性化合物输送的稳定LNs在食品应用中具有显著的潜力.
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