Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antimicrobial Proteins01:23

Antimicrobial Proteins

742
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
742

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Interpretable prediction and generation of ASC-speck aptamers using multiscale deep biological learning models.

Bioinformatics advances·2026
Same author

Discovery of a New Scaffold RSK2 Inhibitor With Virtual and Phenotypical Screening.

ChemMedChem·2026
Same author

RPI-PLMGNN: Enhancing RNA-Protein Interaction Prediction with the Pretrained Large Language Models and Graph Neural Networks.

ACS synthetic biology·2026
Same author

MPMFMol: Multitask Self-Supervised Pretraining with Multimodal Fine-Tuning for Molecular Property Prediction.

Journal of chemical information and modeling·2026
Same author

Quantum computing applications in drug discovery.

Briefings in bioinformatics·2026
Same author

DeepCYP: an integrated deep learning web server for the holistic "pathway-site product" prediction of CYP450 metabolism.

Nucleic acids research·2026
Same journal

Design of Right-Handed D-Sulfonyl-γ-AApeptides with Broad-Spectrum Antimicrobial Activity.

Journal of medicinal chemistry·2026
Same journal

Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia.

Journal of medicinal chemistry·2026
Same journal

Discovery of <b>PIPE-791</b>, A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders.

Journal of medicinal chemistry·2026
Same journal

Dual Targeting of Nucleotidase-Dependent and -Independent Functions via PROTAC-Mediated CD73 Degradation.

Journal of medicinal chemistry·2026
Same journal

Selective Visualization of ROR1-Positive TNBC of the Mesenchymal-Like Subtype Using Peptide-Based <sup>68</sup>Ga-PET Radiotracers.

Journal of medicinal chemistry·2026
Same journal

Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.

Journal of medicinal chemistry·2026
查看所有相关文章

相关实验视频

Updated: May 13, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K

HMAMP:使用超体积驱动的多目标深度生成模型设计高强度的抗菌.

Li Wang1, Yiping Liu1, Xiangzheng Fu2

  • 1College of Computer Science and Electronic Engineering, Hunan University, ChangSha 410082, China.

Journal of medicinal chemistry
|April 15, 2025
PubMed
概括
此摘要是机器生成的。

超量驱动的多目标抗微生物设计 (HMAMP) 可以同时优化多个属性. 这种新的方法增强了抗微生物的发现,在有效性和多样性方面超过了现有的方法.

更多相关视频

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

11.7K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

913

相关实验视频

Last Updated: May 13, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K
Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

11.7K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

913

科学领域:

  • 生物材料科学 生物材料科学
  • 计算化学的计算化学
  • 药物发现 药物发现 药物发现

背景情况:

  • 抗微生物 (AMP) 显示出对抗多药耐药细菌的前景.
  • 当前的生成模型往往忽视了AMP发现的多目标性质,导致了高候选人消耗.
  • 同时优化多个AMP属性对于有效的药物开发至关重要.

研究的目的:

  • 引入一种新的方法,即超量驱动的多目标AMP设计 (HMAMP),用于同时优化多属性AMP.
  • 通过结合多目标优化来解决AMP发现中现有的生成模型的局限性.
  • 提高产生的抗微生物的有效性和多样性.

主要方法:

  • 强化学习和梯度下降算法的协同集成,基于超体积最大化.
  • 使用HMAMP来偏向生成过程并减轻模式崩.
  • 采用基于膝盖的决策策略,快速选有前途的候选人.

主要成果:

  • 在AMP的有效性和多样性方面,HMAMP显著超过了最先进的方法.
  • 这种方法成功地对生成过程产生偏见,并解决模式崩.
  • 一个基于膝盖的策略有效地识别了具有理想属性的候选人.

结论:

  • 在AMP设计中,HMAMP为导航复杂的搜索空间提供了一个有效的策略.
  • 该方法有助于发现抗微生物,平衡理想性质与现实的约束.
  • HMAMP增强了新型抗菌生物材料的开发管道.