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在帕金森病中自主参与的评估使用瞳孔测量

Dilek İşcan¹, Ceren Türkoğlu², Elif Arslan³

¹Faculty of Medicine, Department of Neurology, Niğde Ömer Halisdemir University, Niğde, 51240, Turkey. dilekiscann@gmail.com.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|April 15, 2025

概括

瞳孔测量揭示了帕金森病 (PD) 中自主神经系统功能障碍,瞳孔扩张受损与疾病严重程度和治疗相关. 这突显了副交感神经系统在PD进展中的参与.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
自主神经病学自主神经病学

背景情况:

瞳孔光反射 (PLR) 评估自主神经系统 (ANS) 功能,反映了副同情和同情平衡.
众所周知,帕金森病 (PD) 影响了ANS,但特定的瞳孔测量变化及其与疾病指标的相关性需要进一步阐明.

研究的目的:

在帕金森病 (PD) 患者中使用瞳孔测量来调查自主神经系统的变化.
探索学生计量参数,运动阶段 (UPDRS-motor,mHYE) 和 PD 中的莱沃多巴每日相当剂量 (LEDD) 之间的关系.

主要方法:

静态和动态瞳孔测量测量在各种照明条件下进行 (scotopic, mesopic, photopic) 和500 lux.
在PD患者和健康的对照组之间比较了瞳孔测量参数.
统计分析检查了瞳孔测量结果与临床测量 (UPDRS-motor,mHYE,LEDD) 之间的相关性.

主要成果:

在静态瞳孔测量中,PD患者表现出明显较低的美索皮瞳孔直径.
动态瞳孔测量显示,在PD患者中,在18秒内,瞳孔直径减少和扩张速度减慢.
在平均瞳孔膨胀速度和mHYE,UPDRS-motor和LEDD之间观察到显著的负相关性,未接受治疗的患者的膨胀速度较慢.

结论:

在PD中的瞳孔测量变化证实了自主神经系统的参与.
通过瞳孔测量评估的副交感神经系统的功能与帕金森病的运动障碍相关.

关键词:

不同类型的物种学.帕金森病是帕金森氏症的一种疾病.瞳孔光反射是一种反射.瞳孔测量术 (pupillometry) 是指用眼睛测量一个孩子的眼睛.

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