查史,诊断阶段和查检测乳腺癌的死亡率
Sida Huang1, Sarah J Westvold2, Pamela R Soulos2
1Yale School of Public Health, New Haven, Connecticut.
JAMA network open
|April 15, 2025
概括
老年妇女的先前查性乳房造影显著降低了晚期乳腺癌诊断的几率,并降低了乳腺癌死亡率. 定期查对于改善这一人口群的乳腺癌结果至关重要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 查性乳房造影对于早期发现乳腺癌和降低死亡率至关重要.
- 预先查史对不同美国人群的诊断阶段和死亡率的影响需要进一步调查.
研究的目的:
- 调查前查性乳房造影与乳腺癌诊断阶段之间的关联.
- 为了确定先前查性乳房造影是否与乳腺癌特异性死亡率的降低有关.
主要方法:
- 一项队列研究利用了相关的监测,流行病学和最终结果-医疗保险数据.
- 包括在2010-2017年间被诊断患有特定乳腺癌亚型 (ER阳性/HER2阴性) 的70岁以上妇女.
- 在诊断前5年内分析了查乳房扫描史,以及其与诊断阶段和死亡率的关联.
主要成果:
- 在13,028名女性中,77.5%的女性接受过先前查. 预先查与晚期诊断的几率降低了54% (aOR,0.46).
- 预先查显示,乳腺癌特异性死亡率的风险降低了36% (aHR,0.63).
- 经过3-4次先前查,与1次先前查相比,死亡风险降低了37%.
结论:
- 预先查性乳房造影与早期诊断和老年妇女乳腺癌死亡率降低有关.
- 这些发现强调了常规查性乳房造影对于改善乳腺癌结局的重要性.
- 该研究承认观察性研究固有的局限性,包括潜在的混因素.
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