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Updated: May 13, 2025

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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在人 mitochondrial ClpP 蛋白酶中的全激活机制

Monica M Goncalves1, Adwaith B Uday2, Taylor J B Forrester1,2

  • 1Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|April 15, 2025
PubMed
概括

人类ClpP蛋白酶对线粒体质量控制至关重要,矛盾的是被抑制剂激活. 新的结构揭示了它的活性状态,为向癌症治疗铺平了道路,例如急性髓性白血病 (AML) 的向癌症疗法.

关键词:
在ClpP蛋白酶中,在 HDX MS 中.亚洛斯特菌是什么意思?低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.细胞内蛋白质降解的细胞内蛋白质降解

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