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Updated: May 23, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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抑制CDK2会产生一个持久的多倍体癌细胞群

Liliya Tyutyunyk-Massey1, Zibo Chen1, Xiuxia Liu1

  • 1Molecular Pharmacology Program and.

JCI insight
|April 15, 2025
PubMed
概括

准循环素依赖激酶2 (CDK2) 会导致癌细胞死亡,但有些多倍体细胞会存活下来. 结合的CDK2和CDK1或激素抑制可以消除耐药癌细胞.

关键词:
细胞循环的细胞周期在瘤学瘤学.药理学 药理学是指药理学的学科.治疗方法 治疗方法

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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M cyclin...
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