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基于光子计数计算机断层扫描的肝脏铁量化使用基于的对比剂

Jonas Neumann¹, Johannes Haubold, Felix Jergas

¹From the Quantum Optics & Quantum Information (QOQI) group, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany (J.N., J.v.Z.); Siemens Healthineers AG, Forchheim, Germany (J.N., B.S., T.N.); Department of Diagnostic and Interventional Radiology and Neuroradiology, Universitätsklinikum Essen, Essen, Germany (J.H., F.J.); Bayer AG, Berlin, Germany (G.J.); Bayer AG, Berlin, Germany (H.P.).

Investigative radiology

|April 15, 2025

概括

光子计数CT可以在增强对比度的扫描中量化肝脏铁. 使用基于的对比介质进行三种材料分解,为检测关键铁含量提供了临床可行的准确性.

科学领域:

医疗成像医学成像
放射学放射学是一门学科.
生物医学工程生物医学工程

背景情况:

肝脏的铁过载需要准确的量化来管理疾病.
计算机断层扫描 (CT) 是一种常见的成像方式,但对比介质可以干扰铁的量化.
光子计数CT提供光谱数据采集,有可能改善材料分解.

研究的目的:

为了评估肝脏铁量化的准确性,使用光子计数CT.
评估 (I) 和 (W) 基对比介质 (CM) 对铁量化的影响.
为了比较2-材料与3-材料分解的性能,用于在增强型CT扫描中测量铁.

主要方法:

使用商用光子计数CT系统,能够获取4个光谱数据集.
检查了人类形状的腹部幽灵与肝脏组织替代品,铁,和基于I或W的CM.
使用重建的光谱CT图像的材料分解量化铁.

主要成果:

在没有CM的样本中,两种材料分解实现了1.4 mg/mL的铁精度.
基于W的CM导致铁的高估 (精度为2.7-4.7 mg/mL) 在2-4 mgW/mL.
使用基于W的CM进行三种材料分解,显示精度提高 (1.4-1.6毫克/毫升).
基于I的CM显著影响了铁的量化,导致更高的不准确性 (>18-37 mg/mL).

结论:

使用合适的CM进行三种材料分解,使肝脏铁的量化在临床上可行.
基于W的CM优于基于I的CM,用于精确的铁测量.
在使用光子计数光谱成像的增强型CT扫描中,检测肝脏关键铁水平是可行的.

关键词:

计算机断层扫描 (CT) 是一种计算机断层扫描.对比媒介是对比媒介.铁的量化铁的量化肝脏肝脏肝脏肝脏肝脏肝脏多种材料的分解.摄像头计数CT CT 测量频谱CT CT 测试结果的是一种.

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