无症状的皮下塞马格卢提德过量服用:一个病例报告和文献综述
Courtney B Diec1, Elizabeth A Cook2, Nguyet T Nguyen2
1Department of Pharmacy Practice, University of Kansas School of Pharmacy, Lawrence, KS, USA.
Journal of pharmacy practice
|April 15, 2025
概括
这项案例研究发现,一个80岁的男性在服用西马格卢提德过量后 (GLP-1 RA) 没有出现任何不良影响. 建议在GLP-1RA过量管理方面进行支持性护理和监测.
科学领域:
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
- 临床病例报告 临床病例报告
背景情况:
- 作为一种类似葡萄糖类-1受体激动剂 (GLP-1 RA) 的西马格卢提德,可治疗2型糖尿病 (T2DM) 和肥胖症.
- 常见的药物不良反应 (ADR) 是剂量依赖的胃肠道问题;不太常见的ADR包括胰腺炎和急性损伤.
- 有限的文献存在于管理GLP-1RA过量服用,特别是皮下注射塞马格卢提德.
研究的目的:
- 报告一个故意过量服用皮下塞马格卢提德的病例.
- 为了评估后的临床表现和实验室检测结果塞马格卢提德过量.
- 为管理GLP-1RA过量服用提供建议.
主要方法:
- 一个病例报告,是一名80岁的男性患有T2DM和认知障碍,他每天自行服用1毫克皮下塞马格卢提德,持续7天.
- 过量服用后5周进行了临床评估和实验室随访 (功能,肝功能,胰腺酶).
- 对GLP-1RA过量管理现有文献的综述.
主要成果:
- 患者没有报告任何药物不良反应,包括胃肠道不适或低血糖症.
- 血糖水平保持在100-180 mg/dL之间.
- 实验室后续检查显示,功能,肝功能或胰腺酶没有临床显著变化.
结论:
- 过量服用GLP-1RA可能会带来各种各样的临床结果.
- 建议提供支持性护理,包括抗药,液体/电解质校正和低血糖监测.
- 密切监测对于管理塞马格卢提德过量至关重要.
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