人类初级运动皮层中自感激活的层状模式
Lasse Knudsen1,2,3,4, Fanhua Guo1,2, Daniel Sharoh5,6
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, No 15 Datun Road, Chaoyang District, Beijing, 100101, China.
Cerebral cortex (New York, N.Y. : 1991)
|April 15, 2025
概括
这项研究揭示了主要运动皮层 (M1) 的深层在手指运动期间通过自感输入被激活. 这些发现凸显了M1深层在处理身体感觉中的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑成像 人类大脑成像
- 发动机控制器的控制器
背景情况:
- 初级运动皮层 (M1) 对于自身感知至关重要,但其层状处理在人类中尚不清楚.
- 之前在动物身上进行的研究表明,表面层是关键,深层的作用尚未被探索.
- 层状功能磁共振成像 (fMRI) 现在使人类亚毫米分辨率的大脑活动研究成为可能.
研究的目的:
- 调查自感体感应对人类原发动性皮质 (M1) 中深层激活的影响.
- 利用先进的层状fMRI技术进行高分辨率的大脑活动映射.
主要方法:
- 亚毫米分辨率的层状fMRI,特别是使用在7特斯拉的血管空间占用 (VASO) 序列.
- 在10名健康受试者中,被动的手指动作被用来引起自身感受刺激.
- 用两个额外的数据集进行验证,使用超高分辨率 (0.3毫米) 的平衡稳定状态自由前行 (bSSFP) 序列.
主要成果:
- 在M1的深层中观察到显著的激活,以响应自身感受刺激.
- 在不同的fMRI序列中获得了相近的结果,证实了这些发现.
- 在M1中,深层激活与自感输入有关.
结论:
- 初级运动皮层 (M1) 的深层在处理自身感知信息方面发挥着重要作用.
- 这些发现表明M1深层是人类自身感知回路的组成部分.
- 结果支持运动控制的积极推断,强调感官反.
相关概念视频
Motor and Sensory Areas of the Cortex
2.5K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor...
2.5K
Somatosensory, Motor, and Association Cortex
307
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
307
Direct Motor Pathways
1.7K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
1.7K
Somatosensation
36.3K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.3K
Hierarchy of Motor Control
2.3K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
2.3K
Major Somatic Sensory Pathways
725
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
725


