慢性颗粒物暴露对子宫内膜异位症相关的信号通路和疾病进展的影响
Gee Soo Jung1, Jae Hoon Lee2,3, Min Jung Lee2,3
1Department of Integrative Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Molecular human reproduction
|April 15, 2025
概括
暴露于细颗粒物 (PM2.5) 通过改变子宫内膜细胞的基因表达和在小鼠中扩大病变,使子宫内膜异位症恶化. 这表明PM2.5可能会通过雌激素受体调节影响其他依赖雌激素的疾病.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 细颗粒物 (PM2.5) 暴露与子宫内膜异位症风险增加和症状严重程度有关.
- 精确的分子机制和PM2.5和子宫内膜异位症之间的直接关联仍然不清楚.
研究的目的:
- 使用体外和体外模型研究PM2.5在子宫内膜异位症发病和进展中的作用.
- 阐明PM2.5诱导的子宫内膜细胞和子宫内膜病变的变化背后的分子机制.
主要方法:
- 人类子宫内膜 (EM) 细胞被培养并暴露于PM2.5 in vitro.
- 建立了一个由子宫内膜异位症诱导的小鼠模型,并暴露在不同剂量的PM2.5.5中.
- 进行了基因表达分析,包括增殖,亡,炎症和迁移的标志物.
- 评估了雌激素受体 (ER) 表达水平和比率.
主要成果:
- 在体外,重复暴露于PM2.5增加了EM细胞的增殖,抗亡活性和氧化应激.
- 在体内,PM2.5暴露显著扩大了小鼠的子宫内膜病变.
- 暴露于PM2.5上调了参与增殖,亡,炎症和迁移的关键基因.
- 在暴露于PM2.5的小鼠中观察到ERα/ERβ比率的显著下降.
结论:
- 暴露于PM2.5会改变子宫内膜细胞中的基因表达,促进与子宫内膜异位症相关的过程.
- 在体内,PM2.5会加剧子宫内膜病变的生长,可能是通过调节雌激素受体通路.
- 这些发现表明,PM2.5可能会导致其他依赖雌激素的妇科疾病.
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