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Updated: May 5, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

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超越检查点抑制:保持治疗选择的开放性

Urvashi Mitbander Joshi1, Jasmin Hundal2, Jonaphine R Mata3

  • 1Division of Malignant Hematology and Medical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
|April 15, 2025
PubMed
概括

组合免疫检查点抑制剂治疗为转移性黑色素瘤提供了52%的十年生存率. 针对耐药病例,新疗法正在出现,包括T细胞疗法和瘤病毒.

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Feedback Inhibition00:46

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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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There are several types of targeted therapies against...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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