在新生儿疹简单病毒疾病的婴儿中,瓦拉西克洛维尔的药理动力学
Nicole Samies1, Ayesha Ahmed2, David W Kimberlin3
1From the Division of Pediatric Infectious Diseases, Geisinger Medical Center, Danville, Pennsylvania.
在新生儿患有简单疹病毒 (HSV) 疾病的婴儿中,瓦拉基克洛维尔悬浮剂的生物可用性低于预期. 这项研究不建议使用瓦拉克洛维尔治疗新生儿HSV,原因是阿西克洛维尔暴露不足.
科学领域:
- 新生儿药理学 新生儿药理学
- 病毒学 病毒学
- 传染病 传染病 传染病
背景情况:
- 新生儿简单疹病毒 (HSV) 疾病需要长时间住院治疗.
- 减少住院时间可以减轻家庭的压力和医疗费用.
- 口服阿西克洛维尔的生物可用性较差,并且通过肠道给药对家庭护理具有挑战性.
研究的目的:
- 评估新生儿HSV疾病的婴儿中华环维尔悬浮剂的药理动力学概况和生物可用性.
- 为了确定是否可以将瓦拉西克洛维尔作为新生儿HSV治疗中的口服选择.
主要方法:
- 七名患有新生儿HSV疾病的婴儿接受了肠道阿西克洛维尔,随后是口服瓦拉西克洛维尔悬浮剂 (20毫克/千克每8小时).
- 药理动力学采样是在亲体阿西克洛维尔和口服瓦拉西克洛维尔治疗阶段进行的.
- 瓦拉克洛维尔的生物可用性是基于系统性阿西克洛维尔暴露的估计.
主要成果:
- 系统性阿西克洛维尔暴露 (曲线下的面积) 之后的瓦拉西克洛维尔是28.8毫克小时/升.
- 瓦拉克洛维尔估计的平均生物利用率为38.7%.
- 来自瓦拉基克洛维尔的阿西克洛维尔暴露率是亲肠道阿西克洛维尔的2.4倍.
结论:
- 在患有新生儿HSV疾病的婴儿中,瓦拉西克洛维尔的生物可用性低于老年人群.
- 研究的瓦拉基克洛维尔悬浮剂量没有达到适合新生儿HSV治疗的系统性阿西克洛维尔暴露.
- 不建议在新生儿HSV疾病的治疗过程中使用瓦拉基克洛维尔悬浮剂.
更多相关视频
08:04Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
05:53Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
相关概念视频
Factors Affecting Drug Response: Overview
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Retrovirus Life Cycles
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
