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维生素D减轻了Wistar大鼠的慢性压力诱导的丸类固醇生成障碍

Siddhi Srivastava¹, Sukriti Srivastava¹, Vipul Agarwal²

¹Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, U.P. 226025, India.

|April 15, 2025

概括

慢性不可预测的压力 (CUS) 通过影响类固醇生成,损害男性生殖健康. 维生素D补充剂有效地预防了压力诱导的丸损伤,并恢复了大鼠的丸水平.

科学领域:

生殖内分泌学生殖内分泌学
神经内分泌学神经内分泌学
营养生物化学营养生物化学

背景情况:

慢性压力会对男性生殖健康产生负面影响.
降低类固醇生成的功能是压力诱导的男性生殖功能障碍的一个关键机制.
维生素D在生殖健康中的作用需要进一步研究.

研究的目的:

为了验证老鼠的慢性不可预测压力 (CUS) 模型.
研究CUS对丸功能和类固醇生成的影响.
评估维生素D对CUS诱导的丸损伤的保护作用.

主要方法:

大鼠接受了为期8周的CUS模式.
维生素D (10μg/kg) 每周两次给CUS大鼠.
通过行为测试和皮质水平来确认压力.
丸功能通过激素水平,氧化应激标志物和精子形态来评估.
通过免疫组织化学分析的类固醇基因表达 (17β-HSD3,StAR,VDR).

主要成果:

CUS引发了类似焦虑的行为,皮质水平升高和丸功能障碍.
CUS显著降低了血清丸激素和17β-HSD3,StAR和VDR的表达.
维生素D治疗改善了CUS诱导的丸激素和类固醇基因表达的下降.
维生素D可以预防丸,上和精子的组织学损伤.

结论:

CUS是诱导男性生殖功能障碍的有效模型.
维生素D可以保护丸免受压力引起的丸损伤.
维生素D可以通过调节类固醇生成途径和VDR表达来发挥其保护作用.

关键词:

17β-氧类固醇脱酶-3 (17β-HSD3) 的使用.慢性不可预测的压力.丸中的类固醇生成.维生素D 维生素D是一种维生素.维生素D受体 (VDR) 是一种维生素D受体.

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