两种超声衰减成像模式的前性比较,使用不同的频率来评估肝脏肥胖症
Hyeon Ji Jang1, Jong Keon Jang1, Subin Heo1
1Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ultrasonography (Seoul, Korea)
|April 15, 2025
概括
低频衰减成像 (ATI) 显示肝肥胖症的诊断准确度与高频ATI相比,不受皮肤到感兴趣区域距离 (SRD) 的影响. 这一发现有助于进行非侵入性肝脂肪评估.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 诊断性表现 诊断性表现
背景情况:
- 对肝硬化症的非侵入性评估对于管理与代谢功能障碍相关的脂肪性肝病 (MASLD) 至关重要.
- 减弱成像 (ATI) 提供了一种有希望的非侵入性方法来量化肝脏脂肪.
- 将不同的ATI频率进行比较对于优化诊断准确度至关重要.
研究的目的:
- 为了比较低频 (3MHz) 与高频 (4MHz) 衰减成像 (ATI) 的诊断性能,以评估肝硬化.
- 为了评估肝脏脂肪分数 (HFF) 和皮肤与感兴趣区域距离 (SRD) 对ATI测量的影响.
- 为了确定最佳的ATI模式,可靠地诊断肝肥胖症.
主要方法:
- 预期单中心研究涉嫌MASLD的参与者接受肝脏活检或手术.
- 使用低频和高频ATI模式以及SRD同时测量的衰减系数 (AC) 测量.
- 相关性分析 (斯皮尔曼) 和线性回归来评估AC,HFF和SRD之间的关系;诊断性能由AUROC评估.
主要成果:
- 包括119名参与者;73人被诊断为MASLD.
- 低频的ATI产生的交流值 (0.61dB/cm/MHz) 比高频的ATI (0.54dB/cm/MHz) 更高.
- 无论是HFF还是SRD都影响了AC,SRD只影响高频模式;AUROC在模式之间是可比的 (0.751比0.771).
结论:
- 低频的ATI提供更高的AC值和可比的诊断准确性肝肥胖症高频的ATI.
- 低频ATI不受SRD的影响,为一致的测量提供了潜在的优势.
- ATI,特别是低频模式,显示出可靠的非侵入性肝硬化症评估的潜力.
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