住院 Delirium 后的轨迹:COVID-19 后虚弱和认知的长期变化
Julia Minnema1, Lisanne Tap2, Evertine J Abbink3
1Division of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Journal of the American Medical Directors Association
|April 15, 2025
概括
在老年COVID-19患者中,住院妄想与长期认知能力下降有关,但不增加脆弱性或死亡率. 对于那些经历过妄想的人来说,建议进行进一步的随访.
科学领域:
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 痴呆症是老年COVID-19患者经常出现的并发症,通常导致短期的功能和认知障碍.
- 了解这种人群中住院 Delirium 的长期后果对于有效的患者管理至关重要.
研究的目的:
- 为了调查住院 Delirium 与 COVID-19 住院的老年人长期死亡率之间的关联.
- 评估住院妄想对虚弱和认知功能长期变化的影响.
主要方法:
- 分析了两项荷兰多中心队列研究 (COVID-OLD和CliniCo) 的回顾性和前性数据.
- 包括70岁及以上的幸存于COVID-19住院的患者,随访数据是在出院后大约两年收集的.
- 在医院妄被评估使用妄观察查尺度,与多变量回归模型用于分析与脆弱性,认知和死亡率的关联.
主要成果:
- 在随访队列中的436名参与者中,有14.2%的人在医院中经历了妄.
- 住院狂妄症与临床脆弱性尺度或死亡率的长期变化没有显著关联.
- 与没有妄想症的患者相比,患有妄想症的患者长期认知能力下降的发生率显著更高.
结论:
- 老年COVID-19幸存者的住院妄与长期的认知能力下降有关.
- 痴呆症似乎与长期虚弱或死亡率的增加无关.
- 在住院期间经历过妄想的患者,建议定期对认知功能进行后续评估.
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