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Huixin Li¹, Jiabei Han¹, Bing Wang¹

¹Division of Avian Infectious Diseases, the State Key Laboratory for Animal Disease Prevention and Control, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin 150069, China.

|April 15, 2025

概括

在中国发现了10个与L1148疫苗菌株有遗传联系的传染性支气管炎病毒 (IBV) 隔离物. 菌血 (MG) F疫苗接种抑制了IBV抗体反应,可能增加对二次感染的易感性.

科学领域:

鸟类病毒学鸟类病毒学
禽类疾病研究研究
疫苗疗效研究疫苗疗效研究

背景情况:

传染性支气管炎病毒 (IBV) 对全球家禽业构成重大威胁.
新型IBV菌株的出现需要持续监测和表征.
了解不同家禽病原体和疫苗之间的相互作用对于疾病控制至关重要.

研究的目的:

来自中国群的IBV新分离菌株的特征.
调查这些分离物与现有疫苗菌株的遗传关系.
评估Mycoplasma gallisepticum (MG) F疫苗接种对IBV复制和免疫反应的影响.

主要方法:

从患病的中分离并识别了十种IBV菌株.
基因组学分析和IBV分离物的S1基因比较.
一个代表性的IBV分离体 (I0317/22) 的基因组测序.
用IBV和MG F疫苗对无特定病原体 (SPF) 进行实验性接种.
评估病毒复制和中和抗体反应.

主要成果:

十个IBV分离物与欧洲L1148疫苗菌株有遗传关系.
用I0317/22隔离剂注射导致轻微的临床症状和低水平的复制,主要是在呼吸道和消化道.
接种MG F疫苗并没有增强IBV复制.
接种MG F疫苗显著抑制了对IBV分离物I0317/22和I0305/19的中和抗体反应.

结论:

已识别的IBV分离物可能来自L1148疫苗菌株,具有较低的致病性.
接种MG F疫苗可能会损害宿主对IBV的免疫反应,可能增加对二次感染 (如大肠杆菌) 的易感性.
需要进一步的研究,以阐明在IBV感染的背景下,MG F诱导的免疫抑制机制.

关键词:

感染性支气管炎病毒感染性支气管炎病毒 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1148 L1 菌质菌菌菌菌菌菌菌菌菌菌菌.中和抗体的抗体病毒复制是病毒的复制.

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