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Updated: May 13, 2025

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
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自组装蛋白质纳米粒子平台用于疫苗开发中的多价值抗原输送.

Hao Wu1, Ruiqi Weng2, Jiaxuan Li3

  • 1Zhejiang Chinese Medical University, Hangzhou 310053, PR China; Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, PR China.

International journal of pharmaceutics
|April 15, 2025
PubMed
概括

蛋白质纳米粒子疫苗提供增强的抗原递送和持久的免疫反应,加速传染病预防. 本综述强调了它们的优势,设计,辅助剂的使用和临床试验的计算选择.

关键词:
辅助剂的应用 辅助剂的应用抗原呈现方式通过计算设计的蛋白质纳米粒子.蛋白质纳米颗粒 蛋白质纳米颗粒自动组装自动组装

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Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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