用于炎症性肠道疾病治疗的胃肠道pH响应或涂层茶叶多 - 氨酸合物制备
Hui Li1, Shuangshuang Chen1, Yumei Li1
1Pharmaceutical Sciences School, Jinzhou Medical University, Jinzhou 121001, Liaoning, China; Jinzhou Medical University, Jinzhou 121001, Liaoning, China; Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, China.
新的口服肝素纳米球 (HEGNs@Z) 结合了抗炎茶多和对pH敏感的皮. 这种配方通过预防微血栓形成和促进肠道愈合,有效治疗炎症性肠病.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 纳米技术纳米技术
背景情况:
- 炎症性肠病 (IBD) 的发病包括由炎症引起的凝血和微血栓形成.
- 目前的口服肝素供应受到胃肠道稳定性和疗效差的限制.
- 在IBD中微循环障碍需要新的治疗策略.
研究的目的:
- 开发一种稳定,口服可生物利用的肝素配方,用于IBD治疗.
- 为了创建一个核心纳米圈系统 (EGNs@Z) 控制的肝素释放.
- 为了研究配方的联合抗炎和抗凝效应.
主要方法:
- Zein/茶叶多纳米球 (EGNs@Z) 被合成以封装肝素 (HEP).
- 描述包括SEM,TEM和FTIR,以确认结构和封装.
- 在实验室中进行了模拟的消化和凝血试验.
- 用一种急性结肠炎小鼠模型来评估治疗疗效.
主要成果:
- EGNs@Z成功地用50-100nm的外封装了肝素.
- 的外保护了肝素在模拟的胃条件下免受降解.
- 在模拟的肠液中,EGCG纳米圈 (EGN) 和HEP的受控释放发生了.
- 在大肠炎模型中,HEGNs@Z证明了有效的抗凝作用,并促进了结肠愈合.
结论:
- 口服的HEGNs@Z可为IBD提供稳定有效的肝素输送.
- 该配方的双重抗炎和抗凝固特性解决IBD病原性.
- 这种多功能材料为炎症性肠病提供了一个有前途的新疗法.
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