普鲁兰作为持续释放载体用于眼部药物输送:一篇评论
Aarushi Kaith1, Unnati Garg1, Neha Jain1
1Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India.
International journal of biological macromolecules
|April 15, 2025
概括
普鲁兰是来自Aureobasidium pullulans的生物聚合物,为先进的眼部药物递送系统提供了潜力. 它的独特特性可以提高治疗效率和患者治疗眼睛疾病的遵从性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 眼科医生 眼科 眼科
- 药物运输 药物运输 药物运输
背景情况:
- 普鲁兰是一种可生物降解,生物相容的外聚糖,由Aureobasidium pullulans生产.
- 目前的眼科治疗 (局部溶液,凝) 患有低药物接触时间和低生物可用性.
- 这些局限性导致频繁的剂量和患者不适应等疾病的患者遵守格劳科马,AMD和白内障.
研究的目的:
- 审查Pullulan及其衍生物在眼部药物管理中的利用和应用.
- 突出Pullulan在开发眼科疾病的持续释放剂型的潜力.
- 确定未来的研究方向,以优化基于Pullulan的眼疗法.
主要方法:
- 关于pullulan及其衍生物在眼部药物输送中的现有文献的全面批判性审查.
- 对Pullulan与眼科应用相关的物理化学特性进行分析.
- 评估Pullulan在制定先进剂型中的潜力,如眼膜,眼膜和in-situ凝.
主要成果:
- 普鲁兰具有出色的薄膜造性能,可用于活性表面修饰.
- 衍生式普鲁兰促进活性药物成分的结合,使微/纳米颗粒系统成为可能.
- 这些系统适用于受控或持续的药物释放,解决传统眼科解决方案的局限性.
结论:
- 普鲁兰及其衍生品在改善眼部药物输送系统方面显示出显著的前景.
- 基于Pullulan的持续释放配方可以提高治疗结果和患者的遵守性.
- 需要进一步的研究,以充分利用Pullulan在治疗普遍的眼部疾病方面的优势.
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