根据患者报告评估的性结肠炎的肠急性:远程监测计划的结果
Edoardo Carboni1, Francesco Maria Stalla1, Marco Mendolaro1
1Gastroenterology Unit, Mauriziano Hospital, Turin, Italy.
肠急症显著影响性结肠炎 (UC) 患者,与增加的残疾和更差的生活质量相关,即使在缓解期间. 了解这些关联是改善患者管理的关键.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 患者报告的结果
背景情况:
- 肠急性是性结肠炎 (UC) 的一个普遍症状.
- 在UC中,与肠急症相关的特定患者特征和情况仍未得到充分研究.
- 这项研究解决了在现实世界UC患者队列中影响肠急症的因素的需要.
研究的目的:
- 为了研究肠道急迫性和临床特征之间的关联在未经选择的性结肠炎 (UC) 门诊患者中.
- 确定与肠急症的存在和严重程度相关的患者因素和疾病状态.
- 探索紧急情况的发生,即使UC处于临床缓解状态.
主要方法:
- 包括使用IBD工具平台的远程监测计划中的成年UC患者.
- 患者完成了简单的临床结肠炎活动指数 (P-SCCAI) 和在家监测IBD - 性结肠炎 (MIAH-UC) 问卷.
- 用P-SCCAI问题评估了肠道紧迫性,基于当代P-SCCAI和MIAH-UC得分提交的分析.
主要成果:
- 在277名UC患者的2768次事件中,34%的人报告了某种程度的肠急性.
- 中度至严重的急症与女性性别,诊断时的年龄较大,疾病持续时间较长,广泛的UC,更高的疾病活性 (MIAH-UC),更大的残疾 (IBD盘) 和任何医疗治疗有关.
- 在3.8%的缓解事件 (MIAH-UC ≤3.5) 中发生了中度至重度的紧急情况,与诊断时的年龄,疾病持续时间,IBD盘点,治疗和女性性别有关.
结论:
- 肠急症显著影响性结肠炎 (UC) 患者,与增加的残疾,更差的生活质量和更高的抑郁症得分相关.
- 即使在临床缓解,中度至重度的肠急性报告在25个事件中约有1个.
- 缓解期间的紧迫性加剧了与疾病相关的残疾,突出了其在活跃炎症之外的临床重要性.
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