基于成像的生物力学参数,用于评估胸前大动脉动脉瘤大动脉解剖和破裂的风险
Nitish Bhatt1, Hijun Seo2,3, Kate Hanneman4
1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
概括
大动脉生物力学成像技术为胸前大动脉动脉瘤提供了个性化的风险评估. 需要进一步验证以标准化这些先进标记物用于临床使用.
科学领域:
- 心血管成像 - 心血管成像
- 生物机械工程 生物机械工程
- 医疗风险评估 医疗风险评估
背景情况:
- 传统的大动脉大小标准可能不足以进行胸前大动脉动脉瘤个性化风险分层.
- 使用成像的体内生物力学评估为患者风险评估提供了更为定制的方法.
研究的目的:
- 审查和总结当前的体内成像技术来评估大动脉生物力学.
- 探索基于成像的生物力学的潜力,以改善胸前大动脉动脉瘤的风险评估.
主要方法:
- 在MEDLINE,EMBASE和Google学者中进行全面的文献搜索.
- 包括生物力学评估的所有成像方式.
- 不包括临床前/动物研究和腹腔大动脉动脉瘤研究.
主要成果:
- 基于成像的生物力学参数包括基于应变的,基于度的和基于计算建模的指标.
- 应变和刚性参数更容易计算,并且在与大动脉剖析等结果联系方面表现有前途.
- 计算模型提供大动脉壁应力高空间分辨率,但依赖于模型假设.
结论:
- 基于成像的大动脉生物力学代表了个性化风险分层在上升胸前大动脉动脉瘤中的重大进步.
- 临床翻译需要对ex vivo生物力学进行大规模验证,并开发标准化,用户友好的算法.
相关概念视频
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...


